I have nearly finished 1 bottle of small ProBion Clinica. During the first week of intake, I had the feeling of blocked throat (actually I think it's the upper part of esophagus connecting to the throat). This feeling lasted for whole day when I took 1 tablet each morning after breakfast - was not feeling comfortable for the whole week and thus wanted to give up taking. Eventually I decided to give it a try for one more week. Amazingly, the blocked throat feeling disappeared after one week. I can feel my stool soften, shortening my time at toilet. I will continue to take it definitely.